How does cell signaling in response to extracellular stressors impact the trafficking of membrane proteins? In particular, the TORC1 complex plays a key role in this process and while some details of this system have reported, in a recent Journal of Biological Chemistry publication, Andre’s group has revealed new details of this pathway focusing on the general amino acid permease Gap1 as a model cargo. Andre et al. describe a novel and distinct pathway wherein ubiquitylation and downregulation of Gap1 is regulated not only by amino acid-induced activation of TORC1, but also by numerous sources of TORC1 inhibition and cellular stress.
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Bowman, R. (2017). The General Amino Acid Permease Gap1 is Regulated Differentially by TORC1 Activation and Inhibition. D.U.Quark, 2 (1). Retrieved from https://dsc.duq.edu/duquark/vol2/iss1/2