D.U.Quark
Article Title
Abstract
Neuropathic pain caused by peripheral nerve injury (PNI) leads to the activation and infiltration of microglial cells and to a neuroinflammatory-induced pain state. miRNAs and autophagy are two main factors and/or mechanisms which have the ability to alter the pain state. In this study, miR-195 was shown to be markedly increased after PNI and associated with the pain phenotype. In addition, inhibition of autophagy in vivo led to p62 accumulation, decreased production of LC3, and inhibition of ATG14.
Instructor
Dr. O'Donnell
First Page
35
Last Page
40
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Recommended Citation
Stevens, A. (2017). Autophagy Inhibition in Pain: Role of a microRNA. D.U.Quark, 2 (1). Retrieved from https://dsc.duq.edu/duquark/vol2/iss1/5