Chemistry and Biochemistry
Bayer School of Natural and Environmental Sciences
H. M. Skip Kingston
Stephanie J. Wetzel
Ellen S. Gawalt
Glyphosate, Illicit drugs, Nerve agents, Solid phase extraction, TOF-MS
The quantitative analysis of environmental and toxicological samples must be reliable, rapid, and in some cases field portable. In the United States, the employment of chemical weapons by rogue states and/or terrorist organizations is an ongoing concern. Nerve agent degradative products (methylphosphonic acid) as well as surrogates (glyphosate) must be detected at low quantities in various water matrices. Current methods involve tedious and time-consuming derivatizations for gas chromatography-mass spectrometry and liquid chromatography in tandem with mass spectrometry. Two solid phase extraction (SPE) techniques for the analysis of glyphosate and methylphosphonic acid are described with the utilization of isotopically enriched analytes for quantitation using atmospheric pressure chemical ionization-quadrupole-time of flight-mass spectrometry (APCI-Q-TOF-MS) that does not require derivatization.
Wagner, R. (2011). Novel Sample Preparation and TOF-MS Analysis of Environmental and Toxicological Analytes Using EPA Method 6800 (Doctoral dissertation, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1324