Title

Classical and Nonclassical Antifolates: Synthesis of Furo-[2,3-d] Pyrimidines Pyrrolo[2,3-d]Pyrimidines and Pyrimido-[4, 5-b]-Indoles

Author

Lei Wang

Defense Date

11-4-2010

Graduation Date

Fall 1-1-2010

Availability

Immediate Access

Submission Type

dissertation

Degree Name

PhD

Department

Medicinal Chemistry

School

School of Pharmacy

Committee Chair

Aleem Gangjee

Committee Member

Marc W Harrold

Committee Member

Patrick Flaherty

Committee Member

David J Lapinsky

Committee Member

David A Johnson

Keywords

antifolates, folate transporter

Abstract

The dissertation will give an introduction, background and our research progress in the areas of antifolates. The design and synthesis of both classical and nonclassical bicyclic furo[2,3-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and tricyclic pyrimido[4,5-b]indoles as potential antifolates have been described. As a part of this study, a total of one hundred and fifty-three new compounds have been synthesized and characterized. Of these, sixty-seven final compounds were submitted for biological evaluation.

Format

PDF

Language

English

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