Classical and Nonclassical Antifolates: Synthesis of Furo-[2,3-d] Pyrimidines Pyrrolo[2,3-d]Pyrimidines and Pyrimido-[4, 5-b]-Indoles
School of Pharmacy
Marc W Harrold
David J Lapinsky
David A Johnson
antifolates, folate transporter
The dissertation will give an introduction, background and our research progress in the areas of antifolates. The design and synthesis of both classical and nonclassical bicyclic furo[2,3-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and tricyclic pyrimido[4,5-b]indoles as potential antifolates have been described. As a part of this study, a total of one hundred and fifty-three new compounds have been synthesized and characterized. Of these, sixty-seven final compounds were submitted for biological evaluation.
Wang, L. (2010). Classical and Nonclassical Antifolates: Synthesis of Furo-[2,3-d] Pyrimidines Pyrrolo[2,3-d]Pyrimidines and Pyrimido-[4, 5-b]-Indoles (Doctoral dissertation, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1505