Determination of Elemental Contamination Trends and Hexavalent Chromium in Dietary Supplements
Environmental Science and Management (ESM)
Bayer School of Natural and Environmental Sciences
Dietary supplements, Elemental contaminants, Hexavalent Chromium, ICP-MS, ISDMS metrology, Microwave sample preparation
Dietary supplements may contain xenobiotic contaminants that can be quantified by total elemental or speciation analysis. In this study, two lots of 19 commercially available dietary supplements were analyzed for trends of elemental contamination by using United States Environmental Protection Agency (EPA) Method 3052 for microwave-assisted digestion and EPA Method 6020B for total elemental quantification by inductively coupled plasma mass spectrometry (ICP-MS). Also, the efficiency of three extraction methods (EPA Method 3060A, EDTA-containing alkaline solution, and hot water sonication) for hexavalent chromium [Cr(VI)] was evaluated on a dietary supplement product. The extracts were analyzed by ion-exchange chromatography coupled with ICP-MS employing Speciated Isotope Dilution Mass Spectrometry quantification. The remaining residues were digested by EPA Method 3052 and quantified for trivalent chromium [Cr(III)] by ICP-MS using Isotope Dilution Mass Spectrometry. The study revealed toxic contaminants, such as aluminum, arsenic, cadmium, lead, and Cr(VI), were present in the dietary supplements.
Danso, E. (2013). Determination of Elemental Contamination Trends and Hexavalent Chromium in Dietary Supplements (Master's thesis, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1513