Title

Development of a Kinetic Model to Investigate the Effect of Compositional Variation and a Processing Condition on the Solid-State Degradation of Gabapentin

Defense Date

3-19-2015

Graduation Date

Spring 1-1-2015

Availability

Immediate Access

Submission Type

dissertation

Degree Name

PhD

Department

Pharmaceutics

School

School of Pharmacy

Committee Chair

Ira Buckner

Committee Member

Peter Wildfong

Committee Member

Wilson Meng

Committee Member

Patrick Flaherty

Committee Member

Howard Kingston

Keywords

Compaction, Excipients, gabapentin, Kinetic model, phyico-chemical properties, Solid-state

Abstract

Gabapentin is used in the treatment of seizures and neuropathic pain. Gabapentin undergoes intra-molecular cyclization to form a γ-lactam. The product lactam is twenty times more toxic than gabapentin, causing seizures in animal models. The United States Pharmacopeia (USP) limits the content of lactam in gabapentin formulations to 0.4% w/w. A number of patents have been issued for solid dosage forms formulated to stabilize gabapentin. Despite these efforts, factors contributing to gabapentin’s poor stability in the solid-state have not been explored completely.

It was hypothesized, that physicochemical properties of the excipients and compaction pressure will accelerate the solid-state degradation of gabapentin, increasing the kinetic rate constant for lactam formation. To test the hypotheses, binary mixtures and compacts of gabapentin with different excipients were prepared and stored under accelerated study conditions. The concentration of lactam and gabapentin was measured using a validated analytical method. A concentration dependent catalytic effect by the excipients was determined by mixing different concentrations of the excipient with gabapentin. The effect of excipient particle size was determined by mixing different size fractions of the excipient with gabapentin.

Significant degradation of unprocessed gabapentin in the presence of excipients strongly suggested a catalytic role of the excipients on gabapentin’s degradation. The existing model was expanded to account for the observed catalytic effect of excipients. A relationship was developed between the rate constant for lactam formation and physical properties of the excipients (such as particle size, morphology, molecular weight, molecular cross sectional area and specific surface area). Along with the catalytic effect of the excipients, compaction pressure and powder properties of the excipients such as moisture content, particle size and yield pressure appeared to be other potential contributing factors affecting gabapentin’s degradation.

Format

PDF

Language

English

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