Title

Synthesis of Bicyclic Pyrrolo[2,3-d]Pyrimidines, and Tricyclic Indeno[2,1-d]/[1,2-d]Pyrimidines as Receptor Tyrosine Kinase (RTK) Inhibitors and Antimitotic Agents

Author

Ying Zhao

Defense Date

2-16-2010

Graduation Date

Spring 1-1-2010

Availability

Immediate Access

Submission Type

dissertation

Degree Name

PhD

Department

Medicinal Chemistry

School

School of Pharmacy

Committee Chair

Aleem Gangjee

Committee Member

Marc W Harrold

Committee Member

Patrick T Flaherty

Committee Member

David J Lapinsky

Committee Member

Moji C Adeyeye

Committee Member

J. Douglas Bricker

Committee Member

David A Johnson

Keywords

antimitotic, cancer, inhibitor, mincrotubulin, receptor tyrosin kinase

Abstract

The dissertation will give an introduction, background and our research progress in the areas of receptor tyrosine kinases inhibitors and antimitosis inhibitors. The design and syntheses of bicyclic pyrrolo[2,3-d]pyrimidines, and tricyclic indeno[2,1-d]- and [1,2-d]pyrimidines as receptor tyrosine kinase inhibitors and bicyclic pyrrolo[2,3-d]pyrimidines, and tricyclic indeno[2,1-d]pyrimidines as antimitotic inhibitors have been described. As a part of this study, a total of two hundred and eleven new compounds have been synthesized and characterized. Of these, ninety five final compounds were submitted for biological evaluation.

Format

PDF

Language

English

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