Title

Synthesis of Pyrrolo[2,3-d]Pytimidines and Pytimido[4,5-b]Indoles as Inhibitors of Multiple Receptor Tyrosine Kinases, Folate Metabolizing Enzymes and Tubulin

Author

Nilesh Zaware

Defense Date

10-19-2009

Graduation Date

Fall 1-1-2009

Availability

Immediate Access

Submission Type

dissertation

Degree Name

PhD

Department

Medicinal Chemistry

School

School of Pharmacy

Committee Chair

Aleem Gangjee

Committee Member

Marc W Harrold

Committee Member

Patrick T Flaherty

Committee Member

David J Lapinsky

Committee Member

David A Johnson

Committee Member

J. Douglas Bricker

Keywords

Antifolate, Antitubulin, pyrimido[4, 5-b]indoles, pyrrolo[2, 3-d]pyrimidines, Receptor tyrosine kinase

Abstract

This dissertation deals with the synthesis of substituted pyrrolo[2,3-d]pyrimidines and pyrimido[4,5-b]indoles as potential antitumor agents. The approaches to target tumor cells include inhibition of tumor induced angiogenesis via multiple receptor tyrosine kinase (RTK) inhibition (or) inhibition of the folate metabolizing enzymes - dihydrofolate reductase (DHFR) or thymidylate synthase (TS) (or) inhibition of tubulin.

Format

PDF

Language

English

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