Defense Date
11-5-2018
Graduation Date
Fall 12-21-2018
Availability
One-year Embargo
Submission Type
thesis
Degree Name
MS
Department
Medicinal Chemistry
School
School of Pharmacy
Committee Chair
Aleem Gangjee
Committee Member
Marc W. Harrold
Committee Member
Kevin Tidgewell
Keywords
ANTIFOLATES PYRROLO[2, 3-d] PYRIMIDINE
Abstract
The dissertation will give an introduction, background and current research progress in the areas of antifolates and chemotherapy of anticancer. The design and synthesis of classical 6- substituted pyrrolo[2,3-d]pyrimidines and 5-substituted pyrrolo[2,3-d]pyrimidines as potential antifolates have been described. The design variations include: methylated thiophene regioisomers, fluorinated phenyl regioisomers, thionyl regioisomers on the side chain of pyrrolo[2,3-d]pyrimidines. As a part of this study, a series of new compounds have been synthesized and characterized. Of these, ten final compounds were submitted for biological evaluation.
Language
English
Recommended Citation
Li, X. (2018). Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies (Master's thesis, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1727