Rangos School of Health Sciences
Melanoma, Photoacoustics, Detection, Cancer, Disease-State, Flow Cytometry
Approximately 1 in 50 Americans develop melanoma in their lifetime. Early detection of melanoma is pivotal to the survival of the patient, with a 99% survival rate for 5 or more years after an early diagnosis. Metastasis, or the spread of cancer, increases the chances of cancerous growth in other parts of the body. In this study, we propose the use of photoacoustic flow cytometry as a diagnostic of patient disease state, by closely monitoring the amount of circulating melanoma cells (CMCs) in a patient’s blood before and after chemotherapy treatments. Using this patient data, we were able to make conclusions regarding the progression of cancer in each of the patients. In the future, we hope to use this real time diagnostic as insight to the effectiveness of a patient’s treatment and ideally sculpting a more effective patient- by- patient treatment regimen.
Salvatore, J. (2021). Diagnosis of Melanoma Disease State From Patient Blood Samples Using Photoacoustic Flow Cytometry (Master's thesis, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1994