Defense Date
10-31-2017
Graduation Date
Fall 12-1-2017
Availability
One-year Embargo
Submission Type
thesis
Degree Name
MS
Department
Medicinal Chemistry
School
School of Pharmacy
Committee Chair
Aleem Gangjee
Committee Member
Patrick Flaherty
Committee Member
Marc W. Harrold
Keywords
Anticancer, Antifolate, Pyrrolo[2, 3-d]pyrimidines, chemotherapy, GARFTase inhibitors, Folate Receptor, PCFT, Reduced Folate Carrier, de novo purine synthesis
Abstract
This thesis mainly focuses on the introduction of the background and work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, et. al. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be discussed. Nevertheless, the details of synthesizing these pyrrolo[2,3-d]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-d]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to achieve better yield.
Language
English
Recommended Citation
Yang, S. (2017). Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents (Master's thesis, Duquesne University). Retrieved from https://dsc.duq.edu/etd/225
Included in
Medicinal and Pharmaceutical Chemistry Commons, Natural Products Chemistry and Pharmacognosy Commons, Nucleic Acids, Nucleotides, and Nucleosides Commons, Pharmaceutics and Drug Design Commons