Bayer School of Natural and Environmental Sciences
Prostatic Acid Phosphatase, Hominoids, Seminal Proteins, Gene Regulation, Sperm Competition, Copulatory Plug
Hominoids vary in their mating behavior. Levels of sperm competition vary accordingly. Species in which females mate with a large number of males are expected to experience high levels of sperm competition, such as chimpanzee and bonobo, while polygynous gorillas likely have little or no sperm competition. Coding regions of several seminal proteins have been shown to be experiencing positive selection, but little is known about the regulatory regions of these genes. The 1.7 kb upstream promoter region of prostatic acid phosphatase (ACPP) of human, bonobo, gorilla, orangutan, gibbon, and macaque was cloned into a luciferase reporter vector and transiently transected into a human prostate cancer cell line (LNCaP). The in vitro expression levels were measured and were found to vary. These results are discussed in terms of mating behavior, sperm competition, and the influence of regulatory regions on phenotypic adaptations.
Hooper-Boyd, K. (2008). Evolution of Prostatic Acid Phosphatase (ACPP) Expression in Hominoids (Master's thesis, Duquesne University). Retrieved from https://dsc.duq.edu/etd/661