Defense Date

2-23-2012

Graduation Date

Spring 2012

Availability

Immediate Access

Submission Type

thesis

Degree Name

MS

Department

Pharmacology

School

School of Pharmacy

Committee Chair

David Johnson

Committee Member

Vincent Giannetti

Committee Member

Paula Witt-Enderby

Keywords

Caffeine, Choline, Short term memory, WRAML 2

Abstract

This study sought to determine whether caffeine combined with choline could improve short-term memory in healthy adults. The study tested the effect of choline (2 gm) alone and in combination with several concentrations of caffeine (25 mg, 50mg and 100mg) on short-term verbal and visual memory and attention. The Wide Range Assessment of Memory and Learning-2 was utilized. Choline 2 gm + caffeine 25 mg group showed significantly (p<0.05) higher overall memory performance whereas memory performance in the choline 2 gm + caffeine 50 mg group was significantly impaired compared to placebo. The data suggest that specific combinations of caffeine and choline can either facilitate or impair short-term memory in adults with normal cognitive function. Future studies of caffeine and choline combinations will test memory performance in subjects with memory impairment.

Format

PDF

Language

English

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