Title

Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién

DOI

10.1371/journal.pone.0214193

Authors

Nicole M. Tayler, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Cristopher A. Boya, Acharya Nagarjuna University
Liuris Herrera, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Jamie Moy, Smithsonian Tropical Research Institute
Michelle Ng, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Laura Pineda, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Alejandro Almanza, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Sara Rosero, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Lorena M. Coronado, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Ricardo Correa, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Ricardo Santamaría, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Zuleima Caballero, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Armando A. Durant-Archibold, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP
Kevin J. Tidgewell, Smithsonian Tropical Research Institute
Marcy J. Balunas, University of Connecticut
William H. Gerwick, Skaggs School of Pharmacy & Pharmaceutical Sciences
Alida Spadafora, Asociación Nacional para la Conservación de la Naturaleza (ANCON)
Marcelino Gutiérrez, Acharya Nagarjuna University
Carmenza Spadafora, Instituto De Investigaciones Cientificas Y Servicios De Alta Tecnologia, INDICASAT-AIP

Document Type

Journal Article

Publication Date

4-1-2019

Publication Title

PLoS ONE

Volume

14

Issue

4

Abstract

Cocos nucifera (C. nucifera) (the coconut palm tree) has been traditionally used to fight a number of human diseases, but only a few studies have tested its components against parasites such as those that cause malaria. In this study, C. nucifera samples were collected from a private natural reserve in Punta Patiño, Darien, Panama. The husk, leaves, pulp, and milk of C. nucifera were extracted and evaluated against the parasites that cause Chagas’ disease or American trypanosomiasis (Trypanosoma cruzi), leishmaniasis (Leishmania donovani) and malaria (Plasmodium falciparum), as well as against a line of breast cancer cells. While there was no activity in the rest of the tests, five and fifteen-minute aqueous decoctions of leaves showed antiplasmodial activity at 10% v/v concentration. Removal of some HPLC fractions resulted in loss of activity, pointing to the presence of synergy between the components of the decoction. Chemical molecules were separated and identified using an ultra-performance liquid chromatography (UPLC) approach coupled to tandem mass spectrometry (LC–MS/MS) using atmospheric pressure chemical ionization quadrupole–time of flight mass spectrometry (APCI–Q–TOF–MS) and molecular networking analysis, revealing the presence of compounds including polyphenol, flavone, sterol, fatty acid and chlorophyll families, among others.

Open Access

Gold

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