Title

Visual association cortex links cues with conjunctions of reward and locomotor contexts

DOI

10.1016/j.cub.2022.02.028

Document Type

Journal Article

Publication Date

4-11-2022

Publication Title

Current Biology

Volume

32

Issue

7

First Page

1563

Last Page

1.58E+11

ISSN

9609822

Keywords

association learning, contextual learning, homeostatic balance, longitudinal two-photon calcium imaging, offset responses, postrhinal association cortex, representational drift, tensor component analysis, visual cortex

Abstract

Postrhinal cortex (POR) and neighboring lateral visual association areas are necessary for identifying objects and interpreting them in specific contexts, but how POR neurons encode the same object across contexts remains unclear. Here, we imaged excitatory neurons in mouse POR across tens of days prior to and throughout initial cue-reward learning and reversal learning. We assessed responses to the same cue when it was rewarded or unrewarded, during both locomotor and stationary contexts. Surprisingly, a large class of POR neurons were minimally cue-driven prior to learning. After learning, distinct clusters within this class responded selectively to a given cue when presented in a specific conjunction of reward and locomotion contexts. In addition, another class contained clusters of neurons whose cue responses were more transient, insensitive to reward learning, and adapted over thousands of presentations. These two classes of POR neurons may support context-dependent interpretation and context-independent identification of sensory cues.

Open Access

Green Accepted

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