Title

Pharmacophore comparison and development of recently discovered long chain arylpiperazine and sulfonamide based 5-HT7 ligands

DOI

10.2174/1389557517666170913111533

Document Type

Journal Article

Publication Date

4-1-2018

Publication Title

Mini-Reviews in Medicinal Chemistry

Volume

18

Issue

7

First Page

552

Last Page

560

ISSN

13895575

Keywords

5-HT7, Arylpiperazine, CNS, Drug design, Pharmacophore, Serotonin

Abstract

The serotonin system exerts its effects on the CNS and many peripheral systems. Of the 14 serotonin receptors, the 5-HT7 receptor is the most recently discovered. The 5-HT7 receptor has been shown to be involved in stress reduction, depression, and nociceptive control. Despite the 20 years since the discovery of 5-HT7R, there are still few truly selective ligands. Two of the common scaffolds for 5-HT7R ligands are long chain arylpiperazines (LCAPs) and sulfonamide containing compounds. This review focuses on recently developed (2014-2016) 5-HT7R ligands, their selectivity for the receptor, and suggests the possible new pharmacophore models for these ligands.

Open Access

Green Accepted

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