Title

Oncogenic signaling of MEK5-ERK5

DOI

10.1016/j.canlet.2017.01.034

Document Type

Journal Article

Publication Date

4-28-2017

Publication Title

Cancer Letters

Volume

392

First Page

51

Last Page

59

ISSN

3043835

Keywords

Cellular signaling, Kinase inhibitors, MEK5-ERK5, Mitogen-activated protein kinase, Targeted therapies

Abstract

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK constituents have well-defined roles in oncogenesis, the MEK5 pathway has only recently emerged in cancer research. In this review, we consider the MEK5 signaling cascade, focusing specifically on its involvement in drug resistance and regulation of aggressive cancer phenotypes. Moreover, we explore the role of MEK5/ERK5 in tumorigenesis and metastatic progression, discussing the discrepancies in preclinical studies and assessing its viability as a therapeutic target for anti-cancer agents.

Open Access

Green Accepted

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