Title

Glycerophosphocholine utilization by candida albicans: Role of the git3 transporter in virulence

DOI

10.1074/jbc.M113.505735

Document Type

Journal Article

Publication Date

11-22-2013

Publication Title

Journal of Biological Chemistry

Volume

288

Issue

47

First Page

33939

Last Page

33952

ISSN

219258

Abstract

Background: Glycerophosphocholine (GroPCho) is a phospholipid metabolite found throughout the human body. Results: Loss of Git3 and Git4 in C. albicans abolishes GroPCho transport, and Git3-deficient cells exhibit reduced virulence. Conclusion: The major GroPCho transporter, Git3, is required for full virulence. Significance: This report is the first to identify a eukaryotic GroPCho-specific transporter and the first to implicate GroPCho utilization in pathogenicity.

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