Title

Cleft lip and palate in family members of cancer survivors

DOI

10.3109/07357907.2010.483510

Document Type

Journal Article

Publication Date

10-1-2010

Publication Title

Cancer Investigation

Volume

28

Issue

9

First Page

958

Last Page

962

ISSN

7357907

Keywords

Cancer susceptibility genes, Congenital defects, Family studies

Abstract

The presence of cleft lip with or without cleft palate (CL/P) in family members of cancer patients was investigated. An epidemiological questionnaire including family history of cancer and congenital oral cleft malformations was administered to 168 cancer survivors and a population-based sample of 170 healthy subjects. In the control group, 1.2% reported a family member with CL/P; among cancer survivors the figure was 4.2% (odds ratio: 3.7; 95% confidence interval: 0.75-17.8; p = .07). Among cancer survivors with a family member with CL/P, there was an apparent excess of testicular cancer and melanoma in comparison with the cancer survivors with no family history of CL/P. These preliminary results suggest a common etiologic background for cancer and CL/P. © 2010 Informa Healthcare USA, Inc.

Open Access

Green Accepted

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