Defense Date
11-27-2007
Graduation Date
Fall 2007
Availability
Immediate Access
Submission Type
thesis
Degree Name
MS
Department
Chemistry and Biochemistry
Committee Chair
Mihaila Rita Mihailescu
Committee Member
Tomislav Pintauer
Committee Member
Ellen Gawalt
Keywords
monolayers, stainless steel, cell adhesion, oligo (ethylene glycol)
Abstract
The implantation of SS316L stento in an artery is associated with a number of problems, including restenosis and thrombosis, due to non-specific protein and cell attachment to the biomaterial. One way to reduce non-specific attachment is to alter the interfacial properties of these materials. This may be done using self-assembled monolayers. Model gold surfaces have been extensively studied and oligo (ethylene glycol) monolayers are the standard for protein and cell mitigation. In this study, self-assembled monolayers were formed on the native oxide surface of stainless steel 316L using synthesized and commercially available phosphonic and carboxylic acids terminated with methyl and triethylene glycol moieties to investigate their ability to mitigate non-specific attachment of 3T3 Swiss fibroblast cells over a twenty four hour time period. Results indicate that methyl-terminated phosphonic acids provided the greatest mitigation of cells which is analogous to two studies on model gold substrates but not to most studies comparing the two modifications.
Format
Language
English
Recommended Citation
Papariella, K. (2007). Interfacial Properties of Oligo (ethylene glycol)-Terminated Self-Assembled Monolayers on Stainless Steel 316L (Master's thesis, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1014