Defense Date
9-6-2012
Graduation Date
Fall 2012
Availability
Immediate Access
Submission Type
thesis
Degree Name
MS
Department
Medicinal Chemistry
School
School of Pharmacy
Committee Chair
Aleem Gangjee
Committee Member
Patrick Flaherty
Committee Member
David Lapinsky
Keywords
Antifolate, Drug design, SAR
Abstract
An introduction, background and research progress in the areas of antifolates and antimitotic agents has been reviewed and discussed. Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer chemotherapy and the treatment of infectious diseases. As a part of this study, thirty-five novel compounds were designed and synthesized on the basis of existing clinically active compounds and their crystal structures. These compounds were synthesized and evaluated as single and/or muliple targeted classical and nonclassical antifolates to decrease toxicity and improve the antitumor activity and selectivity of existing therapeutic agents. In addition, bicyclic substituted thieno[2, 3- italic d /italic ]- and theino[3, 2- italic d /italic ]pyrimidines were synthesized as antimitotic agents. These compounds allowed potent inhibition of tumor cells in culture and extended the structure-activity relationship in the antimitotic area.
Format
Language
English
Recommended Citation
Zhou, X. (2012). Synthesis of Bicyclic Thieno[2,3-d]Pyrimidines, Tricyclic Thieno[2,3-d]Pyrimidines and Thieno[3,2-d]Pyrimidines as Classical and Nonclassical Antifolates (Master's thesis, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1413