Defense Date
11-3-2011
Graduation Date
Fall 2011
Availability
Immediate Access
Submission Type
dissertation
Degree Name
PhD
Department
Chemistry and Biochemistry
Committee Chair
H. M. Skip Kingston
Committee Member
Lynne Divis
Committee Member
Rita Mihailescu
Committee Member
Stephanie Wetzel
Keywords
Autism, ICP-MS, Isotope dilution, LC/MS/MS, Mass spectrometry, Speciation
Abstract
Previous work by our research group demonstrated that quantitative chemical analysis of analytes, such as mercury and chromium species, in environmental matrices could be successfully carried out without using calibration curves and with correction for species interconversion by using EPA Method 6800A. This method encompasses isotope dilution mass spectrometry (IDMS) and speciated isotope dilution mass spectrometry (SIDMS), both of which are described in detail in chapter 1. Research described in this dissertation expands upon our earlier work by applying the method to the speciation of mercury in biological matrices, the speciation of glutathione in red blood cells and whole blood, and the analysis of enzyme activity in mammalian tissue.
Format
Language
English
Recommended Citation
Fahrenholz, T. (2011). Application of Speciated Isotopes Dilution Mass Spectronmetry to the Assessment of Human Health and Toxic Exposure (Doctoral dissertation, Duquesne University). Retrieved from https://dsc.duq.edu/etd/529