Chemistry and Biochemistry
Bayer School of Natural and Environmental Sciences
H. M. Skip Kingston
Autism, ICP-MS, Isotope dilution, LC/MS/MS, Mass spectrometry, Speciation
Previous work by our research group demonstrated that quantitative chemical analysis of analytes, such as mercury and chromium species, in environmental matrices could be successfully carried out without using calibration curves and with correction for species interconversion by using EPA Method 6800A. This method encompasses isotope dilution mass spectrometry (IDMS) and speciated isotope dilution mass spectrometry (SIDMS), both of which are described in detail in chapter 1. Research described in this dissertation expands upon our earlier work by applying the method to the speciation of mercury in biological matrices, the speciation of glutathione in red blood cells and whole blood, and the analysis of enzyme activity in mammalian tissue.
Fahrenholz, T. (2011). Application of Speciated Isotopes Dilution Mass Spectronmetry to the Assessment of Human Health and Toxic Exposure (Doctoral dissertation, Duquesne University). Retrieved from https://dsc.duq.edu/etd/529