Sejal Iyer

Defense Date

4-29-2005

Graduation Date

2005

Availability

Immediate Access

Submission Type

dissertation

Degree Name

PhD

Department

Chemistry and Biochemistry

Committee Chair

H. M. Skip Kingston

Committee Member

Mitchell E. Johnson

Committee Member

Omar W. Steward

Committee Member

W. Jeff Hurst

Keywords

Extraction, Microwave, Sample Preparation

Abstract

Authors describe the development of a novel technique, Integrated Microwave Extraction (IME), an enhancement for Microwave Assisted Solvent Extraction (MASE). Solvents are optimized for chemistry and microwave absorption is modified using secondary microwave absorbers enabling traditional solvent applications. The salient features of IME are its equipment integration and secondary heating technology, which are aimed at overcoming deficiencies of MASE. Comparative studies of IME with traditional extraction techniques were carried out. IME will thus prove to be a time saving method with the added advantages of being economical, safe and environmentally friendly process. The data indicates equivalent recoveries for both classes of solvents (polar as well as non-polar) within a 95% confidence interval. Comparable accuracy with increased precision and enabling of a greener environmental extraction process will promote acceptance for IME. The dissertation includes a study carried out in collaboration with American Chemical Society and EPA to verify the feasibility of using performance based approaches for compliance monitoring in place of prescriptive methods currently used. It also includes a clinical study on drugs of abuse like morphine and the improved accuracy and precision for the analytes over the currently used techniques. Some other applications that are included include the extraction of polymer additives, lipids from food products, environmental contaminants from food products, pesticides and compounds of pharmaceutical interest from a variety of matrices. The project was further extended to include the extraction of different analytes from matrices using ionic liquids as extraction media.

Format

PDF

Language

English

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