Crystal structure of 4-bromo--(propyl-carbamo-yl)benzene-sulfonamide

DOI

10.1107/S2056989022003723

Authors

Mustafa Bookwala, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Saloni Patel, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Patrick T. Flaherty, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Peter L. Wildfong, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.

Document Type

Journal Article

Publication Date

5-1-2022

Publication Title

Acta crystallographica. Section E, Crystallographic communications

Volume

78

Issue

Pt 5

First Page

485

Last Page

489

ISSN

2056-9890

Keywords

bromo­propamide, crystal structure, single-crystal XRD, structural analogue

Abstract

The title compound, CHBrNOS, , contains a sulfonyl urea moiety, which possesses potential therapeutic functions (, anti-diabetic and herbicidal). The geometry of is similar to its closely related analogues, chlorpropamide and tolbutamide. This compound crystallizes in the monoclinic space group 2/, having one mol-ecule in its asymmetric unit. The crystal structure of , recorded at 296 K, shows inter-molecular N-H⋯O and C-H⋯O-type infinite hydrogen-bonded chains involving the sulfonyl urea moiety. Hirshfeld surface analysis and the two-dimensional fingerprint plots confirmed hydrogen bonding as the dominant feature in the crystal packing.

Open Access

OA

Preprint

Link to Author Manuscript

Repository Citation

Bookwala, M., Patel, S., Flaherty, P. T., & Wildfong, P. L. (2022). Crystal structure of 4-bromo--(propyl-carbamo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Crystallographic communications, 78 (Pt 5), 485-489. https://doi.org/10.1107/S2056989022003723