MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types

DOI

10.31083/j.fbl2705167

Authors

Khoa Nguyen, Tulane University School of Medicine
Minh N. Tran, Tulane University School of Medicine
Andrew Rivera, Tulane University School of Medicine
Thomas Cheng, Tulane University School of Medicine
Gabrielle O. Windsor, Tulane University School of Medicine
Abraham B. Chabot, Tulane University School of Medicine
Jane E. Cavanaugh, Duquesne University
Bridgette M. Collins-Burow, Tulane University School of Medicine
Sean B. Lee, Tulane University School of Medicine
David H. Drewry, The University of North Carolina at Chapel Hill
Patrick T. Flaherty, Duquesne University
Matthew E. Burow, Tulane University School of Medicine

Document Type

Journal Article

Publication Date

5-23-2022

Publication Title

Frontiers in Bioscience - Landmark

Volume

27

Issue

5

ISSN

27686701

Keywords

MAP kinases; MAPK; MAP3K; understudied kinase; Dark Kinome; Illuminating the Druggable Genome; cancer

Abstract

The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases.

Open Access

Gold

Repository Citation

Nguyen, K., Tran, M., Rivera, A., Cheng, T., Windsor, G., Chabot, A., Cavanaugh, J., Collins-Burow, B., Lee, S., Drewry, D., Flaherty, P., & Burow, M. (2022). MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types. Frontiers in Bioscience - Landmark, 27 (5). https://doi.org/10.31083/j.fbl2705167