The Tale of DJ-1 (PARK7): A Swiss Army Knife in Biomedical and Psychological Research

DOI

10.3390/ijms24087409

Document Type

Journal Article

Publication Date

4-1-2023

Publication Title

International Journal of Molecular Sciences

Volume

24

Issue

8

ISSN

16616596

Keywords

cancer, DJ-1/PARK7, multifunctional enzyme, psychology, therapeutic target

Abstract

DJ-1 (also known as PARK7) is a multifunctional enzyme in human beings that is highly conserved and that has also been discovered in diverse species (ranging from prokaryotes to eukaryotes). Its complex enzymatic and non-enzymatic activities (such as anti-oxidation, anti-glycation, and protein quality control), as well as its role as a transcriptional coactivator, enable DJ-1 to serve as an essential regulator in multiple cellular processes (e.g., epigenetic regulations) and make it a promising therapeutic target for diverse diseases (especially cancer and Parkinson’s disease). Due to its nature as a Swiss army knife enzyme with various functions, DJ-1 has attracted a large amount of research interest, from different perspectives. In this review, we give a brief summary of the recent advances with respect to DJ-1 research in biomedicine and psychology, as well as the progress made in attempts to develop DJ-1 into a druggable target for therapy.

Open Access

Gold

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