Cardiovascular Molecular Imaging With Fluorine-19 MRI: The Road to the Clinic
DOI
10.1161/CIRCIMAGING.123.014742
Document Type
Journal Article
Publication Date
9-1-2023
Publication Title
Circulation. Cardiovascular imaging
Volume
16
Issue
9
First Page
e014742
Keywords
cardiovascular disease, cell tracking, fluorine-19, inflammation, magnetic resonance imaging, thrombosis, translational research, biomedical
Abstract
Fluorine-19 (19F) magnetic resonance imaging is a unique quantitative molecular imaging modality that makes use of an injectable fluorine-containing tracer that generates the only visible 19F signal in the body. This hot spot imaging technique has recently been used to characterize a wide array of cardiovascular diseases and seen a broad range of technical improvements. Concurrently, its potential to be translated to the clinical setting is being explored. This review provides an overview of this emerging field and demonstrates its diagnostic potential, which shows promise for clinical translation. We will describe 19F magnetic resonance imaging hardware, pulse sequences, and tracers, followed by an overview of cardiovascular applications. Finally, the challenges on the road to clinical translation are discussed.
Open Access
Green Accepted
Preprint
Repository Citation
van Heeswijk, R., Bauer, W., Bönner, F., Janjic, J., Mulder, W., Schreiber, L., Schwitter, J., & Flögel, U. (2023). Cardiovascular Molecular Imaging With Fluorine-19 MRI: The Road to the Clinic. Circulation. Cardiovascular imaging, 16 (9), e014742. https://doi.org/10.1161/CIRCIMAGING.123.014742