Identifying Protein Interactions with Viral DNA Genomes during Virus Infection

DOI

10.3390/v16060845

Document Type

Journal Article

Publication Date

6-1-2024

Publication Title

Viruses

Volume

16

Issue

6

Keywords

DNA repair, DNA replication, DNA virus, DNA–protein interaction, gene transcription, nucleus, viral replication compartment

Abstract

Viruses exploit the host cell machinery to enable infection and propagation. This review discusses the complex landscape of DNA virus–host interactions, focusing primarily on herpesviruses and adenoviruses, which replicate in the nucleus of infected cells, and vaccinia virus, which replicates in the cytoplasm. We discuss experimental approaches used to discover and validate interactions of host proteins with viral genomes and how these interactions impact processes that occur during infection, including the host DNA damage response and viral genome replication, repair, and transcription. We highlight the current state of knowledge regarding virus–host protein interactions and also outline emerging areas and future directions for research.

Open Access

Gold

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