Quiescent behavior in response to bacterial infection in C. elegans

DOI

10.17912/micropub.biology.001412

Authors

Daniel Moses, Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania, United States.
Carly A. Needham, Biology and Health Sciences, Commonwealth University - Bloomsburg.
Hilary DeBardeleben, Biology and Health Sciences, Commonwealth University - Bloomsburg.

Document Type

Journal Article

Publication Date

1-1-2025

Publication Title

microPublication biology

Volume

2025

Abstract

Sickness behaviors serve an important role in recovery from infection. Using the WorMotel and a motivated displacement assay, we show that C. elegans engages in quiescent behavior following infection with Serratia marcesens , a bacterial pathogen. This quiescence is increased with increasing severity of the infection. Furthermore, we show this behavior is distinct from stress-induced sleep due to a lack of feeding quiescence and regulation by sleep-inducing neurons.

Open Access

40114851 (pubmed); PMC11923603 (pmc); 10.17912/micropub.biology.001412 (doi)

Preprint

Link to Free Full Text

Repository Citation

Moses, D., Needham, C. A., & DeBardeleben, H. (2025). Quiescent behavior in response to bacterial infection in C. elegans. microPublication biology, 2025. https://doi.org/10.17912/micropub.biology.001412