Cranial synchondroses of primates at birth

Timothy D. Smith, School of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania, USA.
Rebecca L. Reynolds, Department of Biology, Slippery Rock University, Slippery Rock, Pennsylvania, USA.
Nanami Mano, School of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania, USA.
Brody J. Wood, School of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania, USA.
Lanre Oladipupo, School of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania, USA.
Gabriel K. Hughes, School of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania, USA.
Hayley M. Corbin, Department of Biology, Slippery Rock University, Slippery Rock, Pennsylvania, USA.
Jane Taylor, Department of Biomedical Education and Anatomy, The Ohio State College of Medicine, Columbus, Ohio, USA.
Alexander Ufelle, Department of Biology, Slippery Rock University, Slippery Rock, Pennsylvania, USA.
Anne M. Burrows, Department of Physical Therapy, Duquesne University, Pittsburgh, Pennsylvania, USA.
Emily Durham, Department of Anthropology, Penn State University, State College, Pennsylvania, USA.
Christopher J. Vinyard, Department of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, Ohio, USA.
James J. Cray, Department of Biomedical Education and Anatomy, The Ohio State College of Medicine, Columbus, Ohio, USA.
Valerie B. DeLeon, Department of Public Health and Social Work, Slippery Rock University, Slippery Rock, PA.

Abstract

Cranial synchondroses are cartilaginous joints between basicranial bones or between basicranial bones and septal cartilage, and have been implicated as having a potential active role in determining craniofacial form. However, few studies have examined them histologically. Using histological and immunohistochemical methods, we examined all basicranial joints in serial sagittal sections of newborn heads from nine genera of primates (five anthropoids, four strepsirrhines). Each synchondrosis was examined for characteristics of active growth centers, including a zonal distribution of proliferating and hypertrophic chondrocytes, as well as corresponding changes in matrix characteristics (i.e., density and organization of Type II collagen). Results reveal three midline and three bilateral synchondroses possess attributes of active growth centers in all species (sphenooccipital, intrasphenoidal, presphenoseptal). One midline synchondrosis (ethmoseptal) and one bilateral synchondrosis (alibasisphenoidal synchondrosis [ABS]) are active growth centers in some but not all newborn primates. ABS is oriented more anteriorly in monkeys compared to lemurs and bushbabies. The sphenoethmoidal synchondrosis (SES) varies at birth: in monkeys, it is a suture-like joint (i.e., fibrous tissue between the two bones); however, in strepsirrhines, the jugum sphenoidale is ossified while the mesethmoid remains cartilaginous. No species possesses an SES that has the organization of a growth plate. Overall, our findings demonstrate that only four midline synchondroses have the potential to actively affect basicranial angularity and facial orientation during the perinatal timeframe, while the SES of anthropoids essentially transitions toward a "suture-like" function, permitting passive growth postnatally. Loss of cartilaginous continuity at SES and reorientation of ABS distinguish monkeys from strepsirrhines.