HSV-1 DNA Replication-Coordinated Regulation by Viral and Cellular Factors
DOI
10.3390/v13102015
Document Type
Journal Article
Publication Date
10-7-2021
Publication Title
Viruses
Volume
13
Issue
10
Keywords
DNA replication, HSV-1, herpes simplex virus, recombination, replication fork
Abstract
DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription. HSV-1 encodes its own DNA replication machinery, including an origin binding protein (UL9), single-stranded DNA binding protein (ICP8), DNA polymerase (UL30), processivity factor (UL42), and a helicase/primase complex (UL5/UL8/UL52). In addition, HSV-1 utilizes a combination of accessory viral and cellular factors to coordinate viral DNA replication with other viral and cellular processes. The purpose of this review is to outline the roles of viral and cellular proteins in HSV-1 DNA replication and replication-coupled processes, and to highlight how HSV-1 may modify and adapt cellular proteins to facilitate productive infection.
Open Access
OA
Preprint
Repository Citation
Packard, J. E., & Dembowski, J. A. (2021). HSV-1 DNA Replication-Coordinated Regulation by Viral and Cellular Factors. Viruses, 13 (10). https://doi.org/10.3390/v13102015