Title

HSV-1 DNA Replication-Coordinated Regulation by Viral and Cellular Factors

DOI

10.3390/v13102015

Document Type

Journal Article

Publication Date

10-7-2021

Publication Title

Viruses

Volume

13

Issue

10

Keywords

DNA replication, HSV-1, herpes simplex virus, recombination, replication fork

Abstract

DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription. HSV-1 encodes its own DNA replication machinery, including an origin binding protein (UL9), single-stranded DNA binding protein (ICP8), DNA polymerase (UL30), processivity factor (UL42), and a helicase/primase complex (UL5/UL8/UL52). In addition, HSV-1 utilizes a combination of accessory viral and cellular factors to coordinate viral DNA replication with other viral and cellular processes. The purpose of this review is to outline the roles of viral and cellular proteins in HSV-1 DNA replication and replication-coupled processes, and to highlight how HSV-1 may modify and adapt cellular proteins to facilitate productive infection.

Open Access

OA

Preprint

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