Pipelle endometrial biopsy for abnormal uterine bleeding: do patient's pain and anxiety really impact on sampling success rate?

DOI

10.1186/s12905-021-01526-8

Aiym Kaiyrlykyzy, National Laboratory of Astana, Nazarbayev University, Kabanbay Batyr Street, 53, 010000, Nur-Sultan, Kazakhstan.
Faina Linkov, Department of Health Administration and Public Health, John G. Rangos, Sr. School of Health Sciences Duquesne University, 600 Grant St, Pittsburgh, PA, 15282, USA.
Faye Foster, Department of Medicine, Nazarbayev University School of Medicine, Zhanybek-Kerey Khans Street, 5/1, 010000, Nur-Sultan, Kazakhstan. faye.foster@nuedu.kz.
Gauri Bapayeva, Clinical Academic Department of Women's Health, National Research Center of Mother and Child Health, University Medical Center, Turan Ave. 32, 010000, Nur-Sultan, Kazakhstan.
Talshyn Ukybassova, Clinical Academic Department of Women's Health, National Research Center of Mother and Child Health, University Medical Center, Turan Ave. 32, 010000, Nur-Sultan, Kazakhstan.
Gulzhanat Aimagambetova, Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Zhanybek-Kerey Khans Street, 5/1, 010000, Nur-Sultan, Kazakhstan.
Kamila Kenbayeva, Clinical Academic Department of Women's Health, National Research Center of Mother and Child Health, University Medical Center, Turan Ave. 32, 010000, Nur-Sultan, Kazakhstan.
Bakytkali Ibrayimov, Clinical Academic Department of Laboratory Medicine, Pathology and Genetics, University Medical Center, Republican Diagnostic Center, 2 Syganaq Street, Nur-Sultan, 010000, Kazakhstan.
Alla Lyasova, Pathology Bureau of Nur-Sultan City Administration, Zhansugirov Street, 1, 010000, Nur-Sultan, Kazakhstan.
Milan Terzic, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 300 Halket St, Pittsburgh, PA, 15213, USA.

Document Type

Journal Article

Publication Date

11-12-2021

Publication Title

BMC women's health

Volume

21

Issue

1

First Page

393

Keywords

Anxiety, Endometrial sampling, Pain, Pipelle endometrial biopsy, Pipelle failure, Pipelle sampling

Abstract

BACKGROUND: Pipelle endometrial biopsy is vital for the early diagnostics of endometrial pathology and is performed in outpatient setting in minimally invasive manner. One of the reported disadvantages of sampling with Pipelle curette is failure to collect enough tissue for histological analysis. The role of psychological factors such as anxiety and pain sensitivity in obtaining adequate samples is not well known. The study's objective was to explore whether there is relationship between severe pain, anxiety, and the rate of Pipelle failure. METHODS: Study included 158 women with median age of 42 who underwent Pipelle endometrial biopsy at Clinical Academic Department of Women's Health of the University Medical Center (UMC), Nur-Sultan City, Kazakhstan with an abnormal uterine bleeding from June 2019 to April 2021. Women were asked to fill survey on pain, anxiety before, during and after the procedure. RESULTS: 3.8%, 15.19% and 4.43% of women reported severe pain and 39.24%, 34.18% and 14.56% of women reported severe anxiety prior, during and after procedure, respectively. Women who experienced severe pain during procedure tend to be more anxious during procedure (p = 0.0001) and have higher number of sampling attempts (p = 0.0040). Pain level was higher among patients sampled by the junior OB/GYN specialist (p < 0.0001). We found no differences in Pipelle biopsy success rates in relationship to baseline, during and postprocedural pain and anxiety scores. CONCLUSION: Anxiety during procedure performance was significantly associated with severe pain during the procedure but did not represent a key element for the success of Pipelle biopsy.

Open Access

OA

Preprint

Additional Link

Link to Full Text

Share

COinS