Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat
DOI
10.1016/j.jneuroim.2018.02.010
Document Type
Journal Article
Publication Date
5-15-2018
Publication Title
Journal of Neuroimmunology
Volume
318
First Page
72
Last Page
79
ISSN
1655728
Abstract
Neuroinflammation involving macrophages elevates Prostaglandin E2, associated with neuropathic pain. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) inhibits cyclooxygenase, reducing PGE2. However, NSAIDs cause physiological complications. We developed nanoemulsions incorporating celecoxib and near infrared dye. Intravenous injected nanoemulsion is incorporated into monocytes that accumulate at the injury; revealed in live animals by fluorescence. A single dose (celecoxib 0.24 mg/kg) provides targeted delivery in chronic constriction injury rats, resulting in significant reduction in the visualized inflammation, infiltration of macrophages, COX-2 and PGE2. Animals exhibit relief from hypersensitivity persisting at least four-days. The total body burden of drug is reduced by >2000 fold over oral drug delivery.
Open Access
Green Accepted
Preprint
Repository Citation
Janjic, J., Vasudeva, K., Saleem, M., Stevens, A., Liu, L., Patel, S., & Pollock, J. (2018). Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in rat. Journal of Neuroimmunology, 318, 72-79. https://doi.org/10.1016/j.jneuroim.2018.02.010