Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke
DOI
10.1016/j.expneurol.2015.03.005
Document Type
Journal Article
Publication Date
10-1-2015
Publication Title
Experimental Neurology
Volume
272
First Page
170
Last Page
180
ISSN
144886
Keywords
Angiogenesis, Angiopoietin 1, Docosahexaenoic acid, Eicosapentaenoic acid, Neurogenesis, Oligodendrocyte precursor cell, Oligodendrogenesis, Revascularization
Abstract
Stroke is a devastating neurological disease with no satisfactory therapies to preserve long-term neurological function, perhaps due to the sole emphasis on neuronal survival in most preclinical studies. Recent studies have revealed the importance of protecting multiple cell types in the injured brain, such as oligodendrocytes and components of the neurovascular unit, before long-lasting recovery of function can be achieved. For example, revascularization in the ischemic penumbra is critical to provide various neurotrophic factors that enhance the survival and activity of neurons and other progenitor cells, such as oligodendrocyte precursor cells. In the present study, we hypothesized that chronic dietary supplementation with fish oil promotes post-stroke angiogenesis, neurogenesis, and oligodendrogenesis, thereby leading to long-term functional improvements. Mice received dietary supplementation with n-3 PUFA-enriched fish oil for three months before and up to one month after stroke. As expected, dietary n-3 PUFAs significantly increased levels of n-3 PUFAs in the brain and improved long-term behavioral outcomes after cerebral ischemia. n-3 PUFAs also robustly improved revascularization and angiogenesis and boosted the survival of NeuN/BrdU labeled newborn neurons up to 35. days after stroke injury. Furthermore, these pro-neurogenic effects were accompanied by robust oligodendrogenesis. Thus, this is the first study to demonstrate that chronic dietary intake of n-3 PUFAs is an effective prophylactic measure not only to protect against ischemic injury for the long term but also to actively promote neurovascular restorative dynamics and brain repair.
Open Access
Green Accepted
Preprint
Repository Citation
Zhang, W., Wang, H., Zhang, H., Leak, R., Shi, Y., Hu, X., Gao, Y., & Chen, J. (2015). Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke. Experimental Neurology, 272, 170-180. https://doi.org/10.1016/j.expneurol.2015.03.005