In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain
DOI
10.1016/j.jneuroim.2015.04.012
Document Type
Journal Article
Publication Date
6-15-2015
Publication Title
Journal of Neuroimmunology
Volume
283
First Page
43
Last Page
49
ISSN
1655728
Keywords
Chronic constriction injury, Dynamic bayesian network, IL-18, Neuroinflammation, Neuropathic pain
Abstract
Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy.
Open Access
Green Accepted
Preprint
Repository Citation
Vasudeva, K., Vodovotz, Y., Azhar, N., Barclay, D., Janjic, J., & Pollock, J. (2015). In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain. Journal of Neuroimmunology, 283, 43-49. https://doi.org/10.1016/j.jneuroim.2015.04.012