Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases

DOI

10.2174/1871527316666170102120211

Document Type

Journal Article

Publication Date

1-1-2017

Publication Title

CNS and Neurological Disorders - Drug Targets

Volume

16

Issue

3

First Page

326

Last Page

338

ISSN

18715273

Keywords

Acute brain injury, Dietary, Neurodegenerative disease, Nrf2

Abstract

Central nervous system diseases are major health issues and are often associated with disability or death. Most central nervous system disorders are characterized by high levels of oxidative stress. Nuclear factor erythroid 2 related factor (Nrf2) is known for its ability to regulate the expression of a series of enzymes with antioxidative, prosurvival, and detoxification effects. Under basal conditions, Nrf2 forms a complex with Kelch-like ECH associated protein 1, leading to Nrf2 inactivation via ubiquitination and degradation. However, following exposure of Keap1 to oxidative stress, Nrf2 is released from Keap1, activated, and translocated into the nucleus. Upon nuclear entry, Nrf2 binds to antioxidant response elements (ARE), thereby inducing the expression of genes such as glutathione s-transferase, heme oxygenase 1, and NADPH quinine oxidoreductase 1. Many dietary phytochemicals have been reported to activate the protective Nrf2/ARE pathway. Here, we review the preventive and protective effects of dietary Nrf2 activators against CNS diseases, including stroke, traumatic brain injury, Alzheimer’s disease, and Parkinson’s disease.

Open Access

Green Accepted

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