Title

Nitrite reductase and nitric-oxide synthase activity of the mitochondrial molybdopterin enzymes mARC1 and mARC2

DOI

10.1074/jbc.M114.555177

Document Type

Journal Article

Publication Date

4-11-2014

Publication Title

Journal of Biological Chemistry

Volume

289

Issue

15

First Page

10345

Last Page

10358

ISSN

219258

Abstract

Background: Nitrite reduction pathways are critical for biological NO production under hypoxia. Results: The mitochondrial enzyme mARC reduces nitrite to NO using cytochrome b5 as electron donor. Conclusion:mARCforms an electron transfer chain withNADH,cytochrome b5, and cytochrome b5 reductase to reduce nitrite to NO. Significance: mARC proteins may constitute a new pathway for hypoxic NO production in vivo. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

Open Access

Green Final

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