NIR-labeled perfluoropolyether nanoemulsions for drug delivery and imaging
DOI
10.1016/j.jfluchem.2012.02.004
Document Type
Journal Article
Publication Date
5-1-2012
Publication Title
Journal of Fluorine Chemistry
Volume
137
First Page
27
Last Page
33
ISSN
221139
Keywords
19 F MRI, Drug delivery, Imaging, NIR, PFPE, Theranostic
Abstract
Theranostic nanoparticle development recently took center stage in the field of drug delivery nanoreagent design. Theranostic nanoparticles combine therapeutic delivery systems (liposomes, micelles, nanoemulsions, etc.) with imaging reagents (MRI, optical, PET, CT). This combination allows for non-invasive in vivo monitoring of therapeutic nanoparticles in diseased organs and tissues. Here, we report a novel perfluoropolyether (PFPE) nanoemulsion with a water-insoluble lipophilic drug. The formulation enables non-invasive monitoring of nanoemulsion biodistribution using two imaging modalities, 19F MRI and near-infrared (NIR) optical imaging. The nanoemulsion is composed of PFPE-tyramide as a 19F MRI tracer, hydrocarbon oil, surfactants, and a NIR dye. Preparation utilizes a combination of self-assembly and high energy emulsification methods, resulting in droplets with average diameter 180 nm and low polydispersity index (PDI less than 0.2). A model nonsteroidal anti-inflammatory drug (NSAID), celecoxib, was incorporated into the formulation at 0.2 mg/mL. The reported nanoemulsion's properties, including small particle size, visibility under 19F NMR and NIR fluorescence spectroscopy, and the ability to carry drugs make it an attractive potential theranostic agent for cancer imaging and treatment. © 2012 Elsevier B.V.
Open Access
Green Accepted
Preprint
Repository Citation
O'hanlon, C., Amede, K., O'hear, M., & Janjic, J. (2012). NIR-labeled perfluoropolyether nanoemulsions for drug delivery and imaging. Journal of Fluorine Chemistry, 137, 27-33. https://doi.org/10.1016/j.jfluchem.2012.02.004