Glycerophosphocholine utilization by candida albicans: Role of the git3 transporter in virulence

DOI

10.1074/jbc.M113.505735

Authors

Andrew C. Bishop, Duquesne University
Shantanu Ganguly, Carnegie Mellon University
Norma V. Solis, Harbor-UCLA Medical Center
Benjamin M. Cooley, Duquesne University
Michael I. Jensen-Seaman, Duquesne University
Scott G. Filler, Harbor-UCLA Medical Center
Aaron P. Mitchell, Carnegie Mellon University
Jana Patton-Vogt, Duquesne University

Document Type

Journal Article

Publication Date

11-22-2013

Publication Title

Journal of Biological Chemistry

Volume

288

Issue

47

First Page

33939

Last Page

33952

ISSN

219258

Abstract

Background: Glycerophosphocholine (GroPCho) is a phospholipid metabolite found throughout the human body. Results: Loss of Git3 and Git4 in C. albicans abolishes GroPCho transport, and Git3-deficient cells exhibit reduced virulence. Conclusion: The major GroPCho transporter, Git3, is required for full virulence. Significance: This report is the first to identify a eukaryotic GroPCho-specific transporter and the first to implicate GroPCho utilization in pathogenicity.

Open Access

Green Final

Repository Citation

Bishop, A., Ganguly, S., Solis, N., Cooley, B., Jensen-Seaman, M., Filler, S., Mitchell, A., & Patton-Vogt, J. (2013). Glycerophosphocholine utilization by candida albicans: Role of the git3 transporter in virulence. Journal of Biological Chemistry, 288 (47), 33939-33952. https://doi.org/10.1074/jbc.M113.505735