Yeast Pgc1p (YPL206c) controls the amount of phosphatidylglycerol via a phospholipase C-type degradation mechanism
DOI
10.1074/jbc.M800868200
Document Type
Journal Article
Publication Date
6-20-2008
Publication Title
Journal of Biological Chemistry
Volume
283
Issue
25
First Page
17107
Last Page
17115
ISSN
219258
Abstract
The product of the open reading frame YPL206c, Pgc1p, of the yeast Saccharomyces cerevisiae displays homology to bacterial and mammalian glycerophosphodiester phosphodiesterases. Deletion of PGC1 causes an accumulation of the anionic phospholipid, phosphatidylglycerol (PG), especially under conditions of inositol limitation. This PG accumulation was not caused by increased production of phosphatidylglycerol phosphate or by decreased consumption of PG in the formation of cardiolipin, the end product of the pathway. PG accumulation in the pgc1Δ strain was caused rather by inactivation of the PG degradation pathway. Our data demonstrate an existence of a novel regulatory mechanism in the cardiolipin biosynthetic pathway in which Pgc1p is required for the removal of excess PG via a phospholipase C-type degradation mechanism. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc.
Open Access
Green Final
Repository Citation
Šimočková, M., Holič, R., Tahotná, D., Patton-Vogt, J., & Griač, P. (2008). Yeast Pgc1p (YPL206c) controls the amount of phosphatidylglycerol via a phospholipase C-type degradation mechanism. Journal of Biological Chemistry, 283 (25), 17107-17115. https://doi.org/10.1074/jbc.M800868200