Integrating the signatures of demic expansion and archaic introgression in studies of human population genomics
DOI
10.1016/j.gde.2016.09.007
Document Type
Journal Article
Publication Date
12-1-2016
Publication Title
Current Opinion in Genetics and Development
Volume
41
First Page
140
Last Page
149
ISSN
0959437X
Abstract
Human population genomic studies have repeatedly observed a decrease in heterozygosity and an increase in linkage disequilibrium with geographic distance from Africa. While multiple demographic models can generate these patterns, many studies invoke the serial founder effect model, in which populations expand from a single origin and each new population's founders represent a subset of genetic variation in the previous population. The model assumes no admixture with archaic hominins, however, recent studies have identified loci in Homo sapiens bearing signatures of archaic introgression. These results appear to contradict the validity of analyses invoking the serial founder effect model, but we show these two perspectives are compatible. We also propose using the serial founder effect model as a null model for determining the signature of archaic admixture in modern human genomes at different geographic and genomic scales.
Open Access
Hybrid_Gold
Repository Citation
Sugden, L., & Ramachandran, S. (2016). Integrating the signatures of demic expansion and archaic introgression in studies of human population genomics. Current Opinion in Genetics and Development, 41, 140-149. https://doi.org/10.1016/j.gde.2016.09.007