Clinical consequences of polypharmacy in elderly

DOI

10.1517/14740338.2013.827660

Authors

Robert L. Maher, Duquesne University
Joseph Hanlon, University of Pittsburgh
Emily R. Hajjar, Thomas Jefferson University

Document Type

Journal Article

Publication Date

1-1-2014

Publication Title

Expert Opinion on Drug Safety

Volume

13

Issue

1

First Page

57

Last Page

65

ISSN

14740338

Keywords

Aged, Drug utilization, Polypharmacy, Suboptimal drug use

Abstract

Introduction: Polypharmacy, defined as the use of multiple drugs or more than are medically necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were searched from January 1, 1986 to June 30, 2013) to identify relevant articles in people aged > 65 years. Areas covered: We present information about: i) prevalence of polypharmacy and unnecessary medication use; ii) negative consequences of polypharmacy; and iii) interventions to improve polypharmacy. Expert opinion: International research shows that polypharmacy is common in older adults with the highest number of drugs taken by those residing in nursing homes. Nearly 50% of older adults take one or more medications that are not medically necessary. Research has clearly established a strong relationship between polypharmacy and negative clinical consequences. Moreover, well-designed interprofessional (often including clinical pharmacist) intervention studies that focus on enrolling high-risk older patients with polypharmacy have shown that they can be effective in reducing aspects of unnecessary prescribing with mixed results on distal health outcomes. © Informa UK, Ltd.

Open Access

Green Accepted

Preprint

Link to Author Manuscript

Repository Citation

Maher, R., Hanlon, J., & Hajjar, E. (2014). Clinical consequences of polypharmacy in elderly. Expert Opinion on Drug Safety, 13 (1), 57-65. https://doi.org/10.1517/14740338.2013.827660