Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether)
DOI
10.1016/j.jfluchem.2014.03.007
Document Type
Journal Article
Publication Date
1-1-2014
Publication Title
Journal of Fluorine Chemistry
Volume
162
First Page
38
Last Page
44
ISSN
221139
Keywords
Fluorous, Microfluidization, Nanoemulsions, Perfluoro(polyethylene glycol dimethyl ether), PFPAEs, PFPEs
Abstract
This is the first report where PFPAE aromatic conjugates and perfluoro(polyethylene glycol dimethyl ether) are combined and formulated as nanoemulsions with droplet size below 100 nm. A perfluoropolyalkylether (PFPAE) aromatic conjugate, 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene, was used as fluorophilic-hydrophilic diblock (FLD) aimed at stabilizing perfluoro(polyethylene glycol dimethyl ether) nanoemulsions. Its effects on colloidal behaviors in triphasic (organic/fluorous/aqueous) nanoemulsions were studied. The addition of FLD construct to fluorous phase led to decrease in PFPAE nanoemulsion droplet size to as low as 85 nm. Prepared nanoemulsions showed high colloidal stability. Our results suggest that these materials represent viable novel approach to fluorous colloid systems design with potential for biomedical and synthetic applications. © 2014 Elsevier B.V.
Open Access
Green Accepted
Preprint
Repository Citation
Mountain, G., Jelier, B., Bagia, C., Friesen, C., & Janjic, J. (2014). Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether). Journal of Fluorine Chemistry, 162, 38-44. https://doi.org/10.1016/j.jfluchem.2014.03.007