Title

Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether)

DOI

10.1016/j.jfluchem.2014.03.007

Document Type

Journal Article

Publication Date

1-1-2014

Publication Title

Journal of Fluorine Chemistry

Volume

162

First Page

38

Last Page

44

ISSN

221139

Keywords

Fluorous, Microfluidization, Nanoemulsions, Perfluoro(polyethylene glycol dimethyl ether), PFPAEs, PFPEs

Abstract

This is the first report where PFPAE aromatic conjugates and perfluoro(polyethylene glycol dimethyl ether) are combined and formulated as nanoemulsions with droplet size below 100 nm. A perfluoropolyalkylether (PFPAE) aromatic conjugate, 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene, was used as fluorophilic-hydrophilic diblock (FLD) aimed at stabilizing perfluoro(polyethylene glycol dimethyl ether) nanoemulsions. Its effects on colloidal behaviors in triphasic (organic/fluorous/aqueous) nanoemulsions were studied. The addition of FLD construct to fluorous phase led to decrease in PFPAE nanoemulsion droplet size to as low as 85 nm. Prepared nanoemulsions showed high colloidal stability. Our results suggest that these materials represent viable novel approach to fluorous colloid systems design with potential for biomedical and synthetic applications. © 2014 Elsevier B.V.

Open Access

Green Accepted

Share

COinS