Expression of cyclin D1, cyclin D2, and N-myc in embryos of the direct developing frog Eleutherodactylus coqui, with a focus on limbs
DOI
10.1016/j.gep.2013.02.005
Document Type
Journal Article
Publication Date
4-8-2013
Publication Title
Gene Expression Patterns
Volume
13
Issue
2022-05-06
First Page
142
Last Page
149
ISSN
1567133X
Keywords
Anuran digit development, Cranial neural crest, Derived life history, Evolution of direct development, Frog, Limb bud, Limb forming field, Midbrain, Tadpole
Abstract
Species of frogs that develop directly have removed the tadpole from their ontogeny and form adult structures precociously. To see whether cell cycle regulators could be involved in this altered embryogenesis, we examined the expression of ccnd1, ccnd2, and mycn in embryos of the direct developing frog, Eleutherodactylus coqui. Notable differences compared to embryos of Xenopus laevis, a species with a tadpole, included prominent expression of ccnd2 in the midbrain and ccnd1 in the mandibular neural crest. The former may contribute to the precocious appearance of the adult-type visual system and the latter to the adult-type jaw. Large domains of ccnd2 and mycn presage the early appearance of limb buds, and ccnd1 and mycn are implicated in digit development. © 2013 Elsevier B.V. All rights reserved.
Open Access
Green Accepted
Preprint
Repository Citation
Nath, K., Fisher, C., & Elinson, R. (2013). Expression of cyclin D1, cyclin D2, and N-myc in embryos of the direct developing frog Eleutherodactylus coqui, with a focus on limbs. Gene Expression Patterns, 13 (2022-05-06), 142-149. https://doi.org/10.1016/j.gep.2013.02.005